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Zhu Lab

Research

We are interested in how cells use surface receptors to sense and respond to the mechanical cues present in their extracellular environment, shaping their behavior and adaptation.

Highlighted

Catch Bonds in Immunology
Catch Bonds in Immunology
Hyun-Kyu Choi, Cheng Zhu
Annual Review of Immunology  ·  25 Apr 2025  ·  10.1146/annurev-immunol-082423-035904

All

2025

Catch Bonds in Immunology
Catch Bonds in Immunology
Hyun-Kyu Choi, Cheng Zhu
Annual Review of Immunology  ·  25 Apr 2025  ·  10.1146/annurev-immunol-082423-035904

2024

Mechanotransduction governs CD40 function and underlies X-linked hyper-IgM syndrome
Mechanotransduction governs CD40 function and underlies X-linked hyper-IgM syndrome
Hyun-Kyu Choi, Stefano Travaglino, Matthias Münchhalfen, Richard Görg, Zhe Zhong, Jintian Lyu, David M. Reyes-Aguilar, Jürgen Wienands, Ankur Singh, Cheng Zhu
Science Advances  ·  15 Nov 2024  ·  doi:10.1126/sciadv.adl5815

2021

The kinetics of E-selectin- and P-selectin-induced intermediate activation of integrin αLβ2 on neutrophils.
The kinetics of E-selectin- and P-selectin-induced intermediate activation of integrin αLβ2 on neutrophils.
Fangyuan Zhou, Fang Zhang, Veronika I Zarnitsyna, Larissa Doudy, Zhou Yuan, Kaitao Li, Rodger P McEver, Hang Lu, Cheng Zhu
Journal of cell science  ·  23 Sep 2021  ·  pmid:34435628
Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus
Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus
Cara T. Motz, Victoria Kabat, Tarun Saxena, Ravi V. Bellamkonda, Cheng Zhu
Advanced Healthcare Materials  ·  02 Aug 2021  ·  doi:10.1002/adhm.202100102
PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition
PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition
Kaitao Li, Zhou Yuan, Jintian Lyu, Eunseon Ahn, Simon J. Davis, Rafi Ahmed, Cheng Zhu
Nature Communications  ·  12 May 2021  ·  doi:10.1038/s41467-021-22965-9
Engineering T cells with improved TCR-CD3 interaction for optimal tumor killing
Engineering T cells with improved TCR-CD3 interaction for optimal tumor killing
Velmurugu Yogambigai, Aswin Natarajan, Chenghao Ge, Zhou Yuan, Kaitao Li, …, Saikiran Beesam, Samantha T Nyovanie, Yury Patskovsky, Cheng Zhu, Michelle Krogsgaard
The Journal of Immunology  ·  01 May 2021  ·  doi:10.4049/jimmunol.206.Supp.25.02
Cooperative ectodomain interaction among TCRαβ, CD3δɛ and CD3γɛ
Cooperative ectodomain interaction among TCRαβ, CD3δɛ and CD3γɛ
Zhou Yuan, Peiwen Cong, Chenghao Ge, Aswin Natarajan, Stefano Travaglino, Michelle Krogsgaard, Cheng Zhu
The Journal of Immunology  ·  01 May 2021  ·  doi:10.4049/jimmunol.206.Supp.25.08

2018

Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment
Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment
Gurpanna Saggu, Koshu Okubo, Yunfeng Chen, Ravi Vattepu, Naotake Tsuboi, …, Steven M. Holland, Robert M. Anthony, Mehmet Sen, Cheng Zhu, Tanya N. Mayadas
Nature Communications  ·  29 Nov 2018  ·  doi:10.1038/s41467-018-07506-1
A TCR mechanotransduction signaling loop induces negative selection in the thymus
A TCR mechanotransduction signaling loop induces negative selection in the thymus
Jinsung Hong, Chenghao Ge, Prithiviraj Jothikumar, Zhou Yuan, Baoyu Liu, …, Xinhua Yu, Khalid Salaita, Brian D. Evavold, Alfred Singer, Cheng Zhu
Nature Immunology  ·  12 Nov 2018  ·  doi:10.1038/s41590-018-0259-z
Shear-induced integrin signaling in platelet phosphatidylserine exposure, microvesicle release, and coagulation
Shear-induced integrin signaling in platelet phosphatidylserine exposure, microvesicle release, and coagulation
Aiming Pang, Yujie Cui, Yunfeng Chen, Ni Cheng, M. Keegan Delaney, Minyi Gu, Aleksandra Stojanovic-Terpo, Cheng Zhu, Xiaoping Du
Blood  ·  02 Aug 2018  ·  doi:10.1182/blood-2017-05-785253
Programmable Multivalent DNA-Origami Tension Probes for Reporting Cellular Traction Forces
Programmable Multivalent DNA-Origami Tension Probes for Reporting Cellular Traction Forces
Palash K. Dutta, Yun Zhang, Aaron T. Blanchard, Chenghao Ge, Muaz Rushdi, Kristin Weiss, Cheng Zhu, Yonggang Ke, Khalid Salaita
Nano Letters  ·  18 Jun 2018  ·  doi:10.1021/acs.nanolett.8b01374

2017

Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl Src kinases
Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases
Hiroshi Nishi, Kazuhiro Furuhashi, Xavier Cullere, Gurpanna Saggu, Mark J. Miller, …, Jeffrey C. Berry, Daniel J. DeAngelo, Cheng Zhu, George C. Tsokos, Tanya N. Mayadas
Journal of Clinical Investigation  ·  11 Sep 2017  ·  doi:10.1172/JCI94039
L-selectin mechanochemistry restricts neutrophil priming in vivo
L-selectin mechanochemistry restricts neutrophil priming in vivo
Zhenghui Liu, Tadayuki Yago, Nan Zhang, Sumith R. Panicker, Ying Wang, Longbiao Yao, Padmaja Mehta-D’souza, Lijun Xia, Cheng Zhu, Rodger P. McEver
Nature Communications  ·  12 May 2017  ·  doi:10.1038/ncomms15196
In situ and in silico kinetic analyses of programmed cell death-1 PD-1 receptor, programmed cell death ligands, and B7-1 protein interaction network
In situ and in silico kinetic analyses of programmed cell death-1 (PD-1) receptor, programmed cell death ligands, and B7-1 protein interaction network
Kaitao Li, Xiaoxiao Cheng, Andreas Tilevik, Simon J. Davis, Cheng Zhu
Journal of Biological Chemistry  ·  01 Apr 2017  ·  doi:10.1074/jbc.M116.763888
Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity
Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity
Vincent C. Luca, Byoung Choul Kim, Chenghao Ge, Shinako Kakuda, Di Wu, Mehdi Roein-Peikar, Robert S. Haltiwanger, Cheng Zhu, Taekjip Ha, K. Christopher Garcia
Science  ·  24 Mar 2017  ·  doi:10.1126/science.aaf9739
Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force
Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force
Padmaja Mehta-D’souza, Arkadiusz G. Klopocki, Vaheh Oganesyan, Simon Terzyan, Timothy Mather, Zhenhai Li, Sumith R. Panicker, Cheng Zhu, Rodger P. McEver
Journal of Biological Chemistry  ·  01 Feb 2017  ·  doi:10.1074/jbc.M116.767186

2016

Effects of anchor structure and glycosylation of Fcγ receptor III on ligand binding affinity
Effects of anchor structure and glycosylation of Fcγ receptor III on ligand binding affinity
Ning Jiang, Wei Chen, Prithiviraj Jothikumar, Jaina M. Patel, Rangaiah Shashidharamurthy, Periasamy Selvaraj, Cheng Zhu
Molecular Biology of the Cell  ·  07 Nov 2016  ·  doi:10.1091/mbc.E16-06-0470
Molecular mechanisms of mechanotransduction in integrin-mediated cell-matrix adhesion
Molecular mechanisms of mechanotransduction in integrin-mediated cell-matrix adhesion
Zhenhai Li, Hyunjung Lee, Cheng Zhu
Experimental Cell Research  ·  01 Nov 2016  ·  doi:10.1016/j.yexcr.2016.10.001
Local Cellular and Cytokine Cues in the Spleen Regulate In Situ T Cell Receptor Affinity, Function, and Fate of CD8 T Cells
Local Cellular and Cytokine Cues in the Spleen Regulate In Situ T Cell Receptor Affinity, Function, and Fate of CD8 + T Cells
Young-Jin Seo, Prithiviraj Jothikumar, Mehul S. Suthar, Cheng Zhu, Arash Grakoui
Immunity  ·  01 Nov 2016  ·  doi:10.1016/j.immuni.2016.10.024
A model for cyclic mechanical reinforcement
A model for cyclic mechanical reinforcement
Zhenhai Li, Fang Kong, Cheng Zhu
Scientific Reports  ·  27 Oct 2016  ·  doi:10.1038/srep35954
Regulation of actin catch-slip bonds with a RhoA-formin module
Regulation of actin catch-slip bonds with a RhoA-formin module
Cho-yin Lee, Jizhong Lou, Kuo-Kuang Wen, Melissa McKane, Suzanne G. Eskin, Peter A. Rubenstein, Shu Chien, Shoichiro Ono, Cheng Zhu, Larry V. McIntire
Scientific Reports  ·  12 Oct 2016  ·  doi:10.1038/srep35058
Flow-Enhanced Stability of Rolling Adhesion through E-Selectin
Flow-Enhanced Stability of Rolling Adhesion through E-Selectin
Quhuan Li, Annica Wayman, Jiangguo Lin, Ying Fang, Cheng Zhu, Jianhua Wu
Biophysical Journal  ·  01 Aug 2016  ·  doi:10.1016/j.bpj.2016.07.014
Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-Based Biosensor
Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-Based Biosensor
Kaitao Li, Xue Xiang, Jie Sun, Hai-Tao He, Jianhua Wu, Yingxiao Wang, Cheng Zhu
Annals of Biomedical Engineering  ·  06 Jul 2016  ·  doi:10.1007/s10439-016-1683-6
Constitutive Lck Activity Drives Sensitivity Differences between CD8 Memory T Cell Subsets
Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets
Duane Moogk, Shi Zhong, Zhiya Yu, Ivan Liadi, William Rittase, …, Cheng Zhu, Navin Varadarajan, Nicholas P Restifo, Alan B Frey, Michelle Krogsgaard
The Journal of Immunology  ·  01 Jul 2016  ·  doi:10.4049/jimmunol.1600178
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
David K. Cole, Anna M. Bulek, Garry Dolton, Andrea J. Schauenberg, Barbara Szomolay, …, John J. Miles, Mark Peakman, Linda Wooldridge, Pierre J. Rizkallah, Andrew K. Sewell
Journal of Clinical Investigation  ·  16 May 2016  ·  doi:10.1172/JCI85679
Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity
Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity
Alberto Elosegui-Artola, Roger Oria, Yunfeng Chen, Anita Kosmalska, Carlos Pérez-González, Natalia Castro, Cheng Zhu, Xavier Trepat, Pere Roca-Cusachs
Nature Cell Biology  ·  11 Apr 2016  ·  doi:10.1038/ncb3336

2015

Regulatory and T Effector Cells Have Overlapping Low to High Ranges in TCR Affinities for Self during Demyelinating Disease
Regulatory and T Effector Cells Have Overlapping Low to High Ranges in TCR Affinities for Self during Demyelinating Disease
Jennifer D Hood, Veronika I Zarnitsyna, Cheng Zhu, Brian D Evavold
The Journal of Immunology  ·  01 Nov 2015  ·  doi:10.4049/jimmunol.1501464
Force-Regulated In Situ TCR Peptide-Bound MHC Class II Kinetics Determine Functions of CD4 T Cells
Force-Regulated In Situ TCR–Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells
Jinsung Hong, Stephen P Persaud, Stephen Horvath, Paul M Allen, Brian D Evavold, Cheng Zhu
The Journal of Immunology  ·  01 Oct 2015  ·  doi:10.4049/jimmunol.1501407
Pre-TCR ligand binding impacts thymocyte development before αβTCR expression
Pre-TCR ligand binding impacts thymocyte development before αβTCR expression
Robert J. Mallis, Ke Bai, Haribabu Arthanari, Rebecca E. Hussey, Maris Handley, …, Hang Lu, Jia-Huai Wang, Cheng Zhu, Gerhard Wagner, Ellis L. Reinherz
Proceedings of the National Academy of Sciences  ·  08 Jun 2015  ·  doi:10.1073/pnas.1504971112
The cellular environment regulates in situ kinetics of T cell receptor interaction with peptide major histocompatibility complex
The cellular environment regulates in situ kinetics of T‐cell receptor interaction with peptide major histocompatibility complex
Baoyu Liu, Wei Chen, Kannan Natarajan, Zhenhai Li, David H. Margulies, Cheng Zhu
European Journal of Immunology  ·  22 May 2015  ·  doi:10.1002/eji.201445358
Molecular Force Spectroscopy on Cells
Molecular Force Spectroscopy on Cells
Baoyu Liu, Wei Chen, Cheng Zhu
Annual Review of Physical Chemistry  ·  01 Apr 2015  ·  doi:10.1146/annurev-physchem-040214-121742

2014

DNA-based digital tension probes reveal integrin forces during early cell adhesion
DNA-based digital tension probes reveal integrin forces during early cell adhesion
Yun Zhang, Chenghao Ge, Cheng Zhu, Khalid Salaita
Nature Communications  ·  24 Oct 2014  ·  doi:10.1038/ncomms6167
A Generalizable, Tunable Microfluidic Platform for Delivering Fast Temporally Varying Chemical Signals to Probe Single-Cell Response Dynamics
A Generalizable, Tunable Microfluidic Platform for Delivering Fast Temporally Varying Chemical Signals to Probe Single-Cell Response Dynamics
Loice Chingozha, Mei Zhan, Cheng Zhu, Hang Lu
Analytical Chemistry  ·  10 Oct 2014  ·  doi:10.1021/ac5019843
Accumulation of Serial Forces on TCR and CD8 Frequently Applied by Agonist Antigenic Peptides Embedded in MHC Molecules Triggers Calcium in T Cells
Accumulation of Serial Forces on TCR and CD8 Frequently Applied by Agonist Antigenic Peptides Embedded in MHC Molecules Triggers Calcium in T Cells
Sergey Pryshchep, Veronika I Zarnitsyna, Jinsung Hong, Brian D Evavold, Cheng Zhu
The Journal of Immunology  ·  01 Jul 2014  ·  doi:10.4049/jimmunol.1303436
Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling
Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling
Baoyu Liu, Wei Chen, Brian D. Evavold, Cheng Zhu
Cell  ·  01 Apr 2014  ·  doi:10.1016/j.cell.2014.02.053

2013

Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis
Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis
Young I. Choi, Jonathan S. Duke-Cohan, Wei Chen, Baoyu Liu, Jérémie Rossy, …, Lining Ju, Jingang Gui, Katharina Gaus, Cheng Zhu, Ellis L. Reinherz
Proceedings of the National Academy of Sciences  ·  16 Dec 2013  ·  doi:10.1073/pnas.1314209111
Hidden Markov Models With Applications in Cell Adhesion Experiments
Hidden Markov Models With Applications in Cell Adhesion Experiments
Ying Hung, Yijie Wang, Veronika Zarnitsyna, Cheng Zhu, C. F. Jeff Wu
Journal of the American Statistical Association  ·  01 Dec 2013  ·  doi:10.1080/01621459.2013.836973
2 scp D TCR scp p scp MHC scp scp CD scp 8 kinetics determines scp T scp cell responses in a self antigen specific scp TCR scp system
2D TCR–pMHC–CD8 kinetics determines T‐cell responses in a self‐antigen‐specific TCR system
Baoyu Liu, Shi Zhong, Karolina Malecek, Laura A. Johnson, Steven A. Rosenberg, Cheng Zhu, Michelle Krogsgaard
European Journal of Immunology  ·  20 Oct 2013  ·  doi:10.1002/eji.201343774
Mechanical regulation of T cell functions
Mechanical regulation of T‐cell functions
Wei Chen, Cheng Zhu
Immunological Reviews  ·  10 Oct 2013  ·  doi:10.1111/imr.12122
Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling
Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling
Yolande Chen, Jorie Aardema, Sayali Kale, Zakary L. Whichard, Arinola Awomolo, …, Gregory A. Voth, Cheng Zhu, Walter H. A. Kahr, Wilbur A. Lam, Seth J. Corey
Blood  ·  05 Sep 2013  ·  doi:10.1182/blood-2013-03-484550
Mechanochemitry: A Molecular Biomechanics View of Mechanosensing
Mechanochemitry: A Molecular Biomechanics View of Mechanosensing
Cheng Zhu
Annals of Biomedical Engineering  ·  05 Sep 2013  ·  doi:10.1007/s10439-013-0904-5
An HMM-based algorithm for evaluating rates of receptor ligand binding kinetics from thermal fluctuation data
An HMM-based algorithm for evaluating rates of receptor–ligand binding kinetics from thermal fluctuation data
Lining Ju, Yijie Dylan Wang, Ying Hung, Chien-Fu Jeff Wu, Cheng Zhu
Bioinformatics  ·  18 Apr 2013  ·  doi:10.1093/bioinformatics/btt180
Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds
Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds
Cho-yin Lee, Jizhong Lou, Kuo-kuang Wen, Melissa McKane, Suzanne G. Eskin, Shoichiro Ono, Shu Chien, Peter A. Rubenstein, Cheng Zhu, Larry V. McIntire
Proceedings of the National Academy of Sciences  ·  04 Mar 2013  ·  doi:10.1073/pnas.1218407110
Cyclic Mechanical Reinforcement of Integrin Ligand Interactions
Cyclic Mechanical Reinforcement of Integrin–Ligand Interactions
Fang Kong, Zhenhai Li, William M. Parks, David W. Dumbauld, Andrés J. García, A. Paul Mould, Martin J. Humphries, Cheng Zhu
Molecular Cell  ·  01 Mar 2013  ·  doi:10.1016/j.molcel.2013.03.008
Cyclic Mechanical Reinforcement of Integrin Ligand Interactions
Cyclic Mechanical Reinforcement of Integrin–Ligand Interactions
Fang Kong, Zhenhai Li, William M. Parks, David W. Dumbauld, Andrés J. García, A. Paul Mould, Martin J. Humphries, Cheng Zhu
Molecular Cell  ·  01 Mar 2013  ·  doi:10.1016/j.molcel.2013.01.015
P-Selectin Glycoprotein Ligand-1 Forms Dimeric Interactions with E-Selectin but Monomeric Interactions with L-Selectin on Cell Surfaces
P-Selectin Glycoprotein Ligand-1 Forms Dimeric Interactions with E-Selectin but Monomeric Interactions with L-Selectin on Cell Surfaces
Yan Zhang, Ning Jiang, Veronika I. Zarnitsyna, Arkadiusz G. Klopocki, Rodger P. McEver, Cheng Zhu
PLoS ONE  ·  25 Feb 2013  ·  doi:10.1371/journal.pone.0057202

2012

Insights from i in situ i analysis of TCR scp pMHC scp recognition: response of an interaction network
Insights from in situ analysis of TCR–pMHC recognition: response of an interaction network
Cheng Zhu, Ning Jiang, Jun Huang, Veronika I. Zarnitsyna, Brian D. Evavold
Immunological Reviews  ·  19 Dec 2012  ·  doi:10.1111/imr.12016
Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells
Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells
Wei Chen, Jizhong Lou, Evan A. Evans, Cheng Zhu
Journal of Cell Biology  ·  29 Oct 2012  ·  doi:10.1083/jcb.201201091
T cell triggering: insights from 2D kinetics analysis of molecular interactions
T cell triggering: insights from 2D kinetics analysis of molecular interactions
Veronika Zarnitsyna, Cheng Zhu
Physical Biology  ·  01 Aug 2012  ·  doi:10.1088/1478-3975/9/4/045005
Catch Bonds of Integrin Ligand Interactions
Catch Bonds of Integrin/Ligand Interactions
Cheng Zhu, Wei Chen
Single-molecule Studies of Proteins  ·  01 Jan 2012  ·  doi:10.1007/978-1-4614-4921-8_3

2011

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex
T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex
Jarrett J. Adams, Samanthi Narayanan, Baoyu Liu, Michael E. Birnbaum, Andrew C. Kruse, …, Aron M. Levin, Janet M. Connolly, Cheng Zhu, David M. Kranz, K. Christopher Garcia
Immunity  ·  01 Nov 2011  ·  doi:10.1016/j.immuni.2011.09.013
A FRET-Based Biosensor for Imaging SYK Activities in Living Cells
A FRET-Based Biosensor for Imaging SYK Activities in Living Cells
Xue Xiang, Jie Sun, Jianhua Wu, Hai-Tao He, Yingxiao Wang, Cheng Zhu
Cellular and Molecular Bioengineering  ·  21 Oct 2011  ·  doi:10.1007/s12195-011-0211-x

2010

Triphasic Force Dependence of E-Selectin Ligand Dissociation Governs Cell Rolling under Flow
Triphasic Force Dependence of E-Selectin/Ligand Dissociation Governs Cell Rolling under Flow
Annica M. Wayman, Wei Chen, Rodger P. McEver, Cheng Zhu
Biophysical Journal  ·  01 Aug 2010  ·  doi:10.1016/j.bpj.2010.05.040
A Model for Single-Substrate Trimolecular Enzymatic Kinetics
A Model for Single-Substrate Trimolecular Enzymatic Kinetics
Wei Chen, Cheng Zhu
Biophysical Journal  ·  01 May 2010  ·  doi:10.1016/j.bpj.2010.01.020
Simulated Thermal Unfolding of the von Willebrand Factor A Domains
Simulated Thermal Unfolding of the von Willebrand Factor A Domains
Wei Chen, Jizhong Lou, Cheng Zhu
Cellular and Molecular Bioengineering  ·  06 Apr 2010  ·  doi:10.1007/s12195-010-0117-z

2009

Demonstration of catch bonds between an integrin and its ligand
Demonstration of catch bonds between an integrin and its ligand
Fang Kong, Andrés J. García, A. Paul Mould, Martin J. Humphries, Cheng Zhu
Journal of Cell Biology  ·  29 Jun 2009  ·  doi:10.1083/jcb.200810002
Bending rigidities of cell surface molecules P-selectin and PSGL-1
Bending rigidities of cell surface molecules P-selectin and PSGL-1
Ying Fang, Jianhua Wu, Rodger P. McEver, Cheng Zhu
Journal of Biomechanics  ·  01 Feb 2009  ·  doi:10.1016/j.jbiomech.2008.11.020
Chapter 7 Biophysical Regulation of Selectin Ligand Interactions Under Flow
Chapter 7 Biophysical Regulation of Selectin–Ligand Interactions Under Flow
Rodger P. McEver, Cheng Zhu
Current Topics in Membranes  ·  01 Jan 2009  ·  doi:10.1016/S1063-5823(09)64007-2

2008

MHC Variant Peptide-Mediated Anergy of Encephalitogenic T Cells Requires SHP-1
MHC Variant Peptide-Mediated Anergy of Encephalitogenic T Cells Requires SHP-1
Heather A. Wasserman, Carrie D. Beal, Yan Zhang, Ning Jiang, Cheng Zhu, Brian D. Evavold
The Journal of Immunology  ·  15 Nov 2008  ·  doi:10.4049/jimmunol.181.10.6843
Flow induces loop-to-β-hairpin transition on the β-switch of platelet glycoprotein Ibα
Flow induces loop-to-β-hairpin transition on the β-switch of platelet glycoprotein Ibα
Jizhong Lou, Cheng Zhu
Proceedings of the National Academy of Sciences  ·  16 Sep 2008  ·  doi:10.1073/pnas.0801965105
Binary Time Series Modeling With Application to Adhesion Frequency Experiments
Binary Time Series Modeling With Application to Adhesion Frequency Experiments
Ying Hung, Veronika Zarnitsyna, Yan Zhang, Cheng Zhu, C. F. Jeff Wu
Journal of the American Statistical Association  ·  01 Sep 2008  ·  doi:10.1198/016214508000000508
Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF
Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF
Tadayuki Yago, Jizhong Lou, Tao Wu, Jun Yang, Jonathan J. Miner, …, Miguel A. Cruz, Jing-Fei Dong, Larry V. McIntire, Rodger P. McEver, Cheng Zhu
Journal of Clinical Investigation  ·  01 Aug 2008  ·  doi:10.1172/JCI35754
Flow-Induced Structural Transition in the β-Switch Region of Glycoprotein Ib
Flow-Induced Structural Transition in the β-Switch Region of Glycoprotein Ib
Zhongzhou Chen, Jizhong Lou, Cheng Zhu, Klaus Schulten
Biophysical Journal  ·  01 Aug 2008  ·  doi:10.1529/biophysj.108.132324
Measuring Diffusion and Binding Kinetics by Contact Area FRAP
Measuring Diffusion and Binding Kinetics by Contact Area FRAP
Timothy P. Tolentino, Jianhua Wu, Veronika I. Zarnitsyna, Ying Fang, Michael L. Dustin, Cheng Zhu
Biophysical Journal  ·  01 Jul 2008  ·  doi:10.1529/biophysj.107.114447
The Differential Effect of Endothelial Cell Factors on In Vitro Motility of Malignant and Non-malignant Cells
The Differential Effect of Endothelial Cell Factors on In Vitro Motility of Malignant and Non-malignant Cells
Adele Wright, Yu-Hua Li, Cheng Zhu
Annals of Biomedical Engineering  ·  09 Apr 2008  ·  doi:10.1007/s10439-008-9489-9
Monitoring Receptor-Ligand Interactions between Surfaces by Thermal Fluctuations
Monitoring Receptor-Ligand Interactions between Surfaces by Thermal Fluctuations
Wei Chen, Evan A. Evans, Rodger P. McEver, Cheng Zhu
Biophysical Journal  ·  01 Jan 2008  ·  doi:10.1529/biophysj.107.117895

2007

Kinetics of MHC-CD8 Interaction at the T Cell Membrane
Kinetics of MHC-CD8 Interaction at the T Cell Membrane
Jun Huang, Lindsay J. Edwards, Brian D. Evavold, Cheng Zhu
The Journal of Immunology  ·  01 Dec 2007  ·  doi:10.4049/jimmunol.179.11.7653
Transport Governs Flow-Enhanced Cell Tethering through L-Selectin at Threshold Shear
Transport Governs Flow-Enhanced Cell Tethering through L-Selectin at Threshold Shear
Tadayuki Yago, Veronika I. Zarnitsyna, Arkadiusz G. Klopocki, Rodger P. McEver, Cheng Zhu
Biophysical Journal  ·  01 Jan 2007  ·  doi:10.1529/biophysj.106.090969

2006

Flow-enhanced adhesion regulated by a selectin interdomain hinge
Flow-enhanced adhesion regulated by a selectin interdomain hinge
Jizhong Lou, Tadayuki Yago, Arkadiusz G. Klopocki, Padmaja Mehta, Wei Chen, Veronika I. Zarnitsyna, Nicolai V. Bovin, Cheng Zhu, Rodger P. McEver
The Journal of Cell Biology  ·  21 Sep 2006  ·  doi:10.1083/jcb.200606056
Probabilistic Modeling of Rosette Formation
Probabilistic Modeling of Rosette Formation
Mian Long, Juan Chen, Ning Jiang, Periasamy Selvaraj, Rodger P. McEver, Cheng Zhu
Biophysical Journal  ·  01 Jul 2006  ·  doi:10.1529/biophysj.106.082909
T cells like a firm molecular handshake
T cells like a firm molecular handshake
Michael L. Dustin, Cheng Zhu
Proceedings of the National Academy of Sciences  ·  13 Mar 2006  ·  doi:10.1073/pnas.0600899103

2005

Thermo-Mechanical Responses of a Surface-Coupled AFM Cantilever
Thermo-Mechanical Responses of a Surface-Coupled AFM Cantilever
Jianhua Wu, Ying Fang, Dong Yang, Cheng Zhu
Journal of Biomechanical Engineering  ·  15 Aug 2005  ·  doi:10.1115/1.2073647

2002

Distinct molecular and cellular contributions to stabilizing selectin-mediated rolling under flow
Distinct molecular and cellular contributions to stabilizing selectin-mediated rolling under flow
Tadayuki Yago, Anne Leppänen, Haiying Qiu, Warren D. Marcus, Matthias U. Nollert, Cheng Zhu, Richard D. Cummings, Rodger P. McEver
The Journal of Cell Biology  ·  12 Aug 2002  ·  doi:10.1083/jcb.200204041
A Micropipet Aspiration System to Measure the Kinetics of Selectin Ligand Interactions
A Micropipet Aspiration System to Measure the Kinetics of Selectin/Ligand Interactions
Jun Huang, Juan Chen, Mian Long, Cheng Zhu
International Journal of Nonlinear Sciences and Numerical Simulation  ·  01 Jan 2002  ·  doi:10.1515/IJNSNS.2002.3.3-4.199

2001

Kinetic Measurements of Cell Surface E-Selectin Carbohydrate Ligand Interactions
Kinetic Measurements of Cell Surface E-Selectin/Carbohydrate Ligand Interactions
Mian Long, Hong Zhao, Kuo-Sen Huang, Cheng Zhu
Annals of Biomedical Engineering  ·  01 Nov 2001  ·  doi:10.1114/1.1415529
Dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flow
Dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flow
Vishwanath Ramachandran, Tadayuki Yago, Terry Kay Epperson, Marcin M. A. Kobzdej, Matthias U. Nollert, Richard D. Cummings, Cheng Zhu, Rodger P. McEver
Proceedings of the National Academy of Sciences  ·  31 Jul 2001  ·  doi:10.1073/pnas.171248098
Diffusion of Microspheres in Shear Flow Near a Wall: Use to Measure Binding Rates between Attached Molecules
Diffusion of Microspheres in Shear Flow Near a Wall: Use to Measure Binding Rates between Attached Molecules
Anne Pierres, Anne-Marie Benoliel, Cheng Zhu, Pierre Bongrand
Biophysical Journal  ·  01 Jul 2001  ·  doi:10.1016/S0006-3495(01)75677-9
Quantifying the Impact of Membrane Microtopology on Effective Two-dimensional Affinity
Quantifying the Impact of Membrane Microtopology on Effective Two-dimensional Affinity
Tom E. Williams, Shanmugam Nagarajan, Periasamy Selvaraj, Cheng Zhu
Journal of Biological Chemistry  ·  01 Apr 2001  ·  doi:10.1074/jbc.M010427200

2000

Modeling Concurrent Binding of Multiple Molecular Species in Cell Adhesion
Modeling Concurrent Binding of Multiple Molecular Species in Cell Adhesion
Cheng Zhu, Tom E. Williams
Biophysical Journal  ·  01 Oct 2000  ·  doi:10.1016/S0006-3495(00)76434-4
Concurrent Binding to Multiple Ligands: Kinetic Rates of CD16b for Membrane-Bound IgG1 and IgG2
Concurrent Binding to Multiple Ligands: Kinetic Rates of CD16b for Membrane-Bound IgG1 and IgG2
Tom E. Williams, Periasamy Selvaraj, Cheng Zhu
Biophysical Journal  ·  01 Oct 2000  ·  doi:10.1016/S0006-3495(00)76435-6
Concurrent and Independent Binding of Fcγ Receptors IIa and IIIb to Surface-Bound IgG
Concurrent and Independent Binding of Fcγ Receptors IIa and IIIb to Surface-Bound IgG
Tom E. Williams, Shanmugam Nagarajan, Periasamy Selvaraj, Cheng Zhu
Biophysical Journal  ·  01 Oct 2000  ·  doi:10.1016/S0006-3495(00)76436-8
The Membrane Anchor Influences Ligand Binding Two-dimensional Kinetic Rates and Three-dimensional Affinity of FcγRIII CD16
The Membrane Anchor Influences Ligand Binding Two-dimensional Kinetic Rates and Three-dimensional Affinity of FcγRIII (CD16)
Scott E. Chesla, Ping Li, Shanmugam Nagarajan, Periasamy Selvaraj, Cheng Zhu
Journal of Biological Chemistry  ·  01 Apr 2000  ·  doi:10.1074/jbc.275.14.10235
Kinetics and mechanics of cell adhesion
Kinetics and mechanics of cell adhesion
Cheng Zhu
Journal of Biomechanics  ·  01 Jan 2000  ·  doi:10.1016/S0021-9290(99)00163-3

1999

Tyrosine replacement in P-selectin glycoprotein ligand-1 affects distinct kinetic and mechanical properties of bonds with P- and L-selectin
Tyrosine replacement in P-selectin glycoprotein ligand-1 affects distinct kinetic and mechanical properties of bonds with P- and L-selectin
Vishwanath Ramachandran, Matthias U. Nollert, Haiying Qiu, Wen-Jun Liu, Richard D. Cummings, Cheng Zhu, Rodger P. McEver
Proceedings of the National Academy of Sciences  ·  23 Nov 1999  ·  doi:10.1073/pnas.96.24.13771
A modified Boyden chamber assay for tumor cell transendothelial migration in vitro
A modified Boyden chamber assay for tumor cell transendothelial migration in vitro
Yu-Hua Li, Cheng Zhu
Clinical & Experimental Metastasis  ·  01 Jul 1999  ·  doi:10.1023/A:1006614232388

1991

A thermodynamic and biomechanical theory of cell adhesion Part I: General formulism
A thermodynamic and biomechanical theory of cell adhesion Part I: General formulism
Cheng Zhu
Journal of Theoretical Biology  ·  01 May 1991  ·  doi:10.1016/S0022-5193(05)80473-4

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